{"created":"2023-06-20T13:42:08.678598+00:00","id":1501,"links":{},"metadata":{"_buckets":{"deposit":"c5a32440-f77a-441c-98bb-a19b3dafa02e"},"_deposit":{"created_by":11,"id":"1501","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"1501"},"status":"published"},"_oai":{"id":"oai:fujijoshi.repo.nii.ac.jp:00001501","sets":["6:56:162:163"]},"author_link":["2344","2347","2341","2340","2346","2336","2342","2339","2337","2343","2338","2345","2348","2335"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"53","bibliographicPageStart":"45","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"藤女子大学QOL研究所紀要"},{"bibliographic_title":"The Bulletin of Studies on QOL and Well-Being","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"AIN-93G 飼料組成のうちコーンスターチの50％を生ナガイモ凍結乾燥物で置き換えた飼\n料を４週間与えた正常マウスにおける肝臓での遺伝子発現パターンの変動をDNA マイクロ\nアレイによって網羅的に分析した。先にヤムイモの食品機能性のひとつとして免疫賦活作用\nが報告されているが、ナガイモの摂取による、それに関連した遺伝子発現変動としてFc受容\n体をコードする遺伝子の中でFcer1g とFcgr2b の発現が増加した。また、MHC クラスIと\nII経路での抗原プロセッシングと抗原提示に関わる遺伝子群が発現増加することが示され\nた。異物代謝では、第II相のglutathione S-transferase遺伝子群の発現が高まった。このこ\nとは、ナガイモの摂取によって発がん物質などの有害物質を水溶性化合物に転換して体外に\n排泄する解毒酵素系が亢進されることを推測させる。糖質や脂質の代謝系に関わる遺伝子群\nについては、コントロール食（ナガイモ非添加食）群との間で発現パターンには違いが認め\nられなかった。","subitem_description_type":"Abstract"},{"subitem_description":"To estimate the beneficial effects of the dietary intake of Chinese yam, nagaimo\n(Dioscorea opposita Thunb.), normal mice were fed a diet containing 20% of the raw\nfreeze-dried tuber powder for 4 weeks. DNA microarray analysis of the liver revealed\nthe notable expression pattern of genes related to the immune system. In addition to\nFcer1g and Fcgr2b encoding the Fc receptor, several genes involved in antigen processing\nand presentation by the MHC I and II pathways were up-regulated, which were\nconsidered to promote the immune response. Moreover, the enhanced gene expression\nof Phase II xenobiotic metabolizing enzymes (e.g., glutathione S-transferase) was also\nobserved. It was, therefore, assumed that the consumption of raw nagaimo would\nfavorably modulate the biotransformation of noxious substances such as carcinogens to\nreadily excrete as the water-soluble form. Compared to the control group, no significant\nchanges in genes involved in glucose and lipid metabolism were found in the\nnagaimo-fed group.","subitem_description_type":"Abstract"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"40020599184","subitem_relation_type_select":"NAID"}}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12218176","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18816274","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 民子"},{"creatorName":"ヤマザキ, タミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"得字, 圭彦"},{"creatorName":"トクチ, ヨシヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 真由美"},{"creatorName":"サトウ, マユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川原, 美香"},{"creatorName":"カワハラ, ミカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大庭, 潔"},{"creatorName":"オオバ, キヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木下, 幹朗"},{"creatorName":"キノシタ, ミキオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西, 正男"},{"creatorName":"オオニシ, マサオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAZAKI, Tamiko ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TOKUJI, Yoshihiko ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SATO, Mayumi ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAWAHARA, Mika ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OHBA, Kiyoshi ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KINOSHITA, Mikio ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OHNISHI, Masao ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2348","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-09-01"}],"displaytype":"detail","filename":"⑥山崎民子氏.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"生ナガイモの経口摂取がマウスの肝臓における遺伝子発現に 及ぼす影響","url":"https://fujijoshi.repo.nii.ac.jp/record/1501/files/⑥山崎民子氏.pdf"},"version_id":"5341292d-28fa-4657-9a50-5c8020d80f79"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ナガイモ","subitem_subject_scheme":"Other"},{"subitem_subject":"食品機能性","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA マイクロアレイ","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫調節","subitem_subject_scheme":"Other"},{"subitem_subject":"異物代謝","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"生ナガイモの経口摂取がマウスの肝臓における遺伝子発現に 及ぼす影響：DNAマイクロアレイ分析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生ナガイモの経口摂取がマウスの肝臓における遺伝子発現に 及ぼす影響：DNAマイクロアレイ分析"},{"subitem_title":"Effects of Oral Intake of Raw Chinese Yam Tubers on Gene Expression in Mice Liver:DNA Microarray Analysis","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"11","path":["163"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-09-01"},"publish_date":"2016-09-01","publish_status":"0","recid":"1501","relation_version_is_last":true,"title":["生ナガイモの経口摂取がマウスの肝臓における遺伝子発現に 及ぼす影響：DNAマイクロアレイ分析"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-20T14:21:35.351213+00:00"}