@article{oai:fujijoshi.repo.nii.ac.jp:00000652,
 author = {坂本, 亘 and 藤井 義博 and SAKAMOTO, Wataru and FUJII Yoshihiro},
 issue = {1},
 month = {Mar},
 note = {メタボリックシンドロームにおいて、もっとも重要な病態は肥満である。肥満は生体が余剰なエネルギーを蓄積していく過程において、脂肪細胞が肥大化し、脂肪細胞数が増加した脂肪組織の過剰状態である。脂肪細胞は脂肪を貯蔵するだけでなく、種々なるアデイポカインを産生、分泌し、重要な生理機能を発揮している。しかしながら、肥満に伴うこれら生理機能の破綻は糖尿病、高血圧、高脂血症、動脈硬化症など生活習慣病の主要な原因となる。この総説では栄養素摂取をめぐって、メタボリックシンドロームと脂肪細胞の関係について論ずる。, The origin of metabolic syndrome is the disordered life style, overeating and lack of exercise, and the accumulation of visceral fat. Namely, obesity is a principal causative factor in the development of metabolic syndrome, a condition that greatly increases the risk of type 2 diabetes, cardiovascular disease and stroke. Adipocytes are not merely storage sites of (fat) triglyceride produced from excessive energy but also secrete various physiologically active substances (adipocytokine) such as tumor necrosis factor-α (TNF-α), resistin, interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), adiponectin, and leptin. Dysregulation of adipocytokine secretion in subjects with visceral accumulation such as hypersecretion of PAI-1, TNF-α and hyposecretion of adiponectin may be an important molecular basis of metabolic syndrome. This paper is reviewed on the relationship between metabolic syndrome and adipocytes in nutrients., 5, KJ00006452263, 総説, General manuscript},
 pages = {5--10},
 title = {メタボリックシンドロームと脂肪細胞},
 volume = {3},
 year = {2008}
}